*Doctor Prescription Required* Please email your prescription for this product to OR provide your email address and name of your eye doctor so that we can reach out for prescription verification.


The only FDA-approved prescription eyedrop
proven to raise upper eyelids in adults with acquired
blepharoptosis (low-lying lids)


• Alpha-adrenergic agonists as a class may impact blood pressure. Advise Upneeq patients with
cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension or hypotension to seek
medical care if their condition worsens.
• Use Upneeq with caution in patients with cerebral or coronary insufficiency or Sjögren’s syndrome. Advise
patients to seek medical care if signs and symptoms of potentiation of vascular insufficiency develop.
• Upneeq may increase the risk of angle closure glaucoma in patients with untreated narrow-angle
glaucoma. Advise patients to seek immediate medical care if signs and symptoms of acute narrow-angle
glaucoma develop.
• Patients should not touch the tip of the single patient-use container to their eye or to any surface, in order
to avoid eye injury or contamination of the solution.

Adverse reactions that occurred in 1-5% of subjects treated with Upneeq were punctate keratitis, conjunctival
hyperemia, dry eye, blurred vision, instillation site pain, eye irritation, and headache.

• Alpha-adrenergic agonists, as a class, may impact blood pressure. Caution in using drugs such as beta
blockers, anti-hypertensives, and/or cardiac glycosides is advised. Caution should also be exercised
in patients receiving alpha adrenergic receptor antagonists such as in the treatment
of cardiovascular disease, or benign prostatic hypertrophy.
• Caution is advised in patients taking monoamine oxidase inhibitors which
can affect the metabolism and uptake of circulating amines.